Motif ID: HOX{A4,D4}.p2

Z-value: 0.890


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HOXD4chr2_+_1770161120.301.4e-01Click!
HOXA4chr7_-_27170351-0.096.7e-01Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_132891460 2.359 NM_175067
TAAR6
trace amine associated receptor 6
chr8_+_17396285 1.522 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr15_+_100173182 1.249 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr7_-_122339186 1.191 NM_139175
RNF133
ring finger protein 133
chr4_-_76944585 0.989 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr17_+_41158741 0.837 NM_005533
IFI35
interferon-induced protein 35
chr1_-_205313309 0.778 KLHDC8A
kelch domain containing 8A
chr4_+_100495972 0.733 MTTP
microsomal triglyceride transfer protein
chr2_+_182850550 0.701 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr5_+_140809957 0.656 PCDHGA12
protocadherin gamma subfamily A, 12
chr20_-_34243118 0.656 RBM12
RNA binding motif protein 12
chr5_-_16738346 0.646 MYO10
myosin X
chr11_-_16424391 0.637 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr3_+_97158453 0.617 NM_173655
EPHA6
EPH receptor A6
chr16_+_31366519 0.576 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr13_-_84456424 0.566 SLITRK1
SLIT and NTRK-like family, member 1
chrY_+_1405508 0.563 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr7_+_107110501 0.562 NM_005295
GPR22
G protein-coupled receptor 22
chrX_+_1455508 0.560 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr5_+_140430960 0.554 NM_013340
PCDHB1
protocadherin beta 1
chr3_-_74570262 0.544 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr9_-_134585107 0.539 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr17_-_26127395 0.519 NOS2
nitric oxide synthase 2, inducible
chr4_+_189060597 0.514 NM_178556
TRIML1
tripartite motif family-like 1
chr12_-_121736110 0.510 NM_006549
NM_153499
NM_153500
NM_172214
NM_172215
NM_172216
CAMKK2





calcium/calmodulin-dependent protein kinase kinase 2, beta





chrX_-_15402469 0.509 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr11_-_4414887 0.499 NM_003141
TRIM21
tripartite motif containing 21
chr10_-_70066594 0.487 PBLD
phenazine biosynthesis-like protein domain containing
chr5_+_140810126 0.484 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr19_-_1021122 0.483 NM_001033026
NM_033420
C19orf6

chromosome 19 open reading frame 6

chr7_-_107880492 0.481 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr11_-_120008738 0.481 TRIM29
tripartite motif containing 29
chr19_-_1020995 0.479 C19orf6
chromosome 19 open reading frame 6
chr20_+_43029973 0.479 HNF4A
hepatocyte nuclear factor 4, alpha
chr2_-_31352489 0.476 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr5_-_147162251 0.472 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr13_-_84456473 0.463 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr11_-_85397215 0.462 NM_152723
CCDC89
coiled-coil domain containing 89
chr5_+_140810181 0.461 PCDHGA12
protocadherin gamma subfamily A, 12
chr3_+_97868169 0.460 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr13_+_97928414 0.455 MBNL2
muscleblind-like 2 (Drosophila)
chr11_-_120008801 0.452 TRIM29
tripartite motif containing 29
chr4_+_74606222 0.452 NM_000584
IL8
interleukin 8
chr12_+_7942025 0.446 NANOG
Nanog homeobox
chr5_+_140810326 0.440 PCDHGA12
protocadherin gamma subfamily A, 12
chr10_+_91061705 0.440 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr2_+_177016112 0.439 NM_014621
HOXD4
homeobox D4
chr7_+_128312345 0.429 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr1_+_152881022 0.423 NM_005547
IVL
involucrin
chr2_-_180427314 0.417 NM_001113398
ZNF385B
zinc finger protein 385B
chr8_+_39792473 0.417 NM_194294
IDO2
indoleamine 2,3-dioxygenase 2
chr1_-_100643770 0.415 NM_144620
LRRC39
leucine rich repeat containing 39
chr2_+_152214105 0.412 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr14_+_23305816 0.400 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr18_-_28742744 0.398 NM_004948
NM_024421
DSC1

desmocollin 1

chr14_-_38064176 0.398 FOXA1
forkhead box A1
chr22_+_26138168 0.396 MYO18B
myosin XVIIIB
chr5_+_152870083 0.384 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chrX_+_53111482 0.382 NM_022117
TSPYL2
TSPY-like 2
chr1_-_150738292 0.378 NM_001199739
NM_004079
CTSS

cathepsin S

chr12_-_53730003 0.375 NM_001173467
SP7
Sp7 transcription factor
chr11_+_128564130 0.371 FLI1
Friend leukemia virus integration 1
chr4_-_74864296 0.370 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr5_-_135290521 0.364 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr15_-_37391893 0.364 MEIS2
Meis homeobox 2
chr5_-_147162264 0.362 JAKMIP2
janus kinase and microtubule interacting protein 2
chr14_-_38064440 0.361 NM_004496
FOXA1
forkhead box A1
chr1_-_207095198 0.360 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr4_+_8951476 0.359 NM_001040071
LOC650293
seven transmembrane helix receptor
chr11_+_33363104 0.356 HIPK3
homeodomain interacting protein kinase 3
chr5_-_147162056 0.355 JAKMIP2
janus kinase and microtubule interacting protein 2
chr11_+_128563955 0.355 FLI1
Friend leukemia virus integration 1
chr4_+_72897520 0.354 NM_004885
NPFFR2
neuropeptide FF receptor 2
chr17_+_25958245 0.354 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_-_9117554 0.354 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr20_+_43030005 0.351 HNF4A
hepatocyte nuclear factor 4, alpha
chr11_+_5372737 0.349 NM_001004750
OR51B6
olfactory receptor, family 51, subfamily B, member 6
chr2_-_165551178 0.348 COBLL1
COBL-like 1
chrX_+_99839789 0.348 NM_022144
TNMD
tenomodulin
chr9_-_19786886 0.346 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr11_-_8892909 0.343 ST5
suppression of tumorigenicity 5
chr5_-_74326723 0.343 NM_016591
GCNT4
glucosaminyl (N-acetyl) transferase 4, core 2
chr5_+_125758818 0.342 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr22_+_26138110 0.342 NM_032608
MYO18B
myosin XVIIIB
chr6_-_46293628 0.341 NM_005822
RCAN2
regulator of calcineurin 2
chr14_+_23305792 0.339 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr19_+_15838833 0.335 NM_013939
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr12_+_18414473 0.335 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr17_-_39023461 0.331 NM_000223
KRT12
keratin 12
chr22_-_36562224 0.329 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr5_+_52776479 0.328 FST
follistatin
chr4_+_70796798 0.327 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr18_+_61223392 0.327 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr13_+_97874704 0.326 MBNL2
muscleblind-like 2 (Drosophila)
chrX_-_63450486 0.321 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr4_+_169013687 0.320 NM_007193
ANXA10
annexin A10
chr2_+_177016337 0.320


chr11_-_118084073 0.319 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr18_+_616671 0.317 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr5_-_160279045 0.317 NM_025153
ATP10B
ATPase, class V, type 10B
chr1_+_205236591 0.315 TMCC2
transmembrane and coiled-coil domain family 2
chr12_+_54447660 0.310 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr12_-_53729429 0.309 NM_152860
SP7
Sp7 transcription factor
chr5_+_140739589 0.307 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr22_-_36635999 0.305 NM_145637
APOL2
apolipoprotein L, 2
chr21_+_19289656 0.302 NM_001204175
NM_001204176
NM_001204177
NM_001204178
CHODL



chondrolectin



chr8_+_54764367 0.301 NM_170587
RGS20
regulator of G-protein signaling 20
chr10_+_86131546 0.300 FAM190B
family with sequence similarity 190, member B
chr12_-_16760935 0.299 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr4_+_71200670 0.294 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr15_+_62359175 0.292 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr6_+_29274402 0.292 NM_030946
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr3_-_189840225 0.291 NM_001134418
LEPREL1
leprecan-like 1
chr3_+_186739643 0.291 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr5_-_16742336 0.291 MYO10
myosin X
chr6_-_132967141 0.285 NM_138327
TAAR1
trace amine associated receptor 1
chr12_+_10460416 0.284 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr17_-_39324423 0.284 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr1_+_20465818 0.284 NM_022819
PLA2G2F
phospholipase A2, group IIF
chr5_-_147162175 0.283 JAKMIP2
janus kinase and microtubule interacting protein 2
chr4_+_108814419 0.281 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr19_-_47735858 0.280 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr5_-_132200476 0.278 NM_005260
GDF9
growth differentiation factor 9
chrX_+_103031797 0.274 PLP1
proteolipid protein 1
chrX_+_72667089 0.274 NM_005193
CDX4
caudal type homeobox 4
chr12_+_54891539 0.272 NCKAP1L
NCK-associated protein 1-like
chr16_-_69385656 0.270 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr17_+_18625335 0.270 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr9_+_33026482 0.269 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr11_-_5271035 0.268 NM_000559
HBG1
hemoglobin, gamma A
chr11_+_71927818 0.267 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr5_-_146435589 0.265 NM_181674
NM_181676
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr5_+_69696805 0.265 SMA4
glucuronidase, beta pseudogene
chr12_+_78225068 0.264 NM_014903
NAV3
neuron navigator 3
chr17_+_19281013 0.263 NM_139032
NM_139033
MAPK7

mitogen-activated protein kinase 7

chr7_-_143991255 0.263 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr12_+_7941994 0.263 NM_024865
NANOG
Nanog homeobox
chr13_+_23755059 0.263 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr3_-_71542628 0.262 FOXP1
forkhead box P1
chr15_-_55563091 0.262 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr16_+_78062985 0.262 NM_001244755
CLEC3A
C-type lectin domain family 3, member A
chr6_+_154407641 0.261 NM_001145287
OPRM1
opioid receptor, mu 1
chrX_+_70765479 0.260 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr2_+_102979096 0.260 NM_003855
IL18R1
interleukin 18 receptor 1
chr19_-_51531283 0.259 NM_001167605
NM_006853
KLK11

kallikrein-related peptidase 11

chr2_+_173686314 0.259 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr5_+_69321071 0.259 NM_001178087
NM_022978
NM_021967
NM_022968
SERF1B

SERF1A

small EDRK-rich factor 1B (centromeric)

small EDRK-rich factor 1A (telomeric)

chr5_+_125695787 0.258 NM_001146319
GRAMD3
GRAM domain containing 3
chr5_+_52776408 0.256 FST
follistatin
chr5_+_140868721 0.253 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr19_-_42931500 0.252 NM_005357
LIPE
lipase, hormone-sensitive
chr2_+_54683276 0.250 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr20_-_17641122 0.250 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr10_-_116392099 0.249 ABLIM1
actin binding LIM protein 1
chr7_+_23749837 0.249 NM_001122833
NM_031414
NM_032944
STK31


serine/threonine kinase 31


chr6_+_6588933 0.248 NM_004271
LY86
lymphocyte antigen 86
chr17_+_25958257 0.248 LGALS9
lectin, galactoside-binding, soluble, 9
chr3_+_32993065 0.245 NM_005508
CCR4
chemokine (C-C motif) receptor 4
chr16_+_77822400 0.244 NM_020927
VAT1L
vesicle amine transport protein 1 homolog (T. californica)-like
chr10_-_48438975 0.242 NM_004962
GDF10
growth differentiation factor 10
chr1_-_12677347 0.240 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr6_-_32806545 0.240 NM_000544
NM_018833
TAP2

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

chr20_-_31239558 0.239 NM_182584
C20orf203
chromosome 20 open reading frame 203
chr17_-_39211462 0.239 NM_033032
KRTAP2-2
keratin associated protein 2-2
chr16_-_90128591 0.238 NM_052996
PRDM7
PR domain containing 7
chr6_+_132873829 0.237 NM_053278
TAAR8
trace amine associated receptor 8
chr12_-_57644905 0.237 NM_145064
STAC3
SH3 and cysteine rich domain 3
chr1_+_47603083 0.236 NM_001010969
CYP4A22
cytochrome P450, family 4, subfamily A, polypeptide 22
chr15_+_89631695 0.233 ABHD2
abhydrolase domain containing 2
chr1_-_42776760 0.231


chr6_+_31913763 0.229 CFB
complement factor B
chr6_+_31913852 0.229 CFB
complement factor B
chr2_-_175712276 0.228 NM_001206602
CHN1
chimerin (chimaerin) 1
chr1_+_92632608 0.227 NM_015237
KIAA1107
KIAA1107
chr13_+_97928196 0.225 MBNL2
muscleblind-like 2 (Drosophila)
chr1_-_13007405 0.224 NM_001010889
PRAMEF6
PRAME family member 6
chr16_-_48266181 0.223 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr6_+_4890225 0.223 NM_001143971
CDYL
chromodomain protein, Y-like
chr7_-_92855780 0.222 NM_001039372
HEPACAM2
HEPACAM family member 2
chr1_-_23342342 0.221 NM_001242521
LOC729059
uncharacterized LOC729059
chr15_+_89631731 0.221 ABHD2
abhydrolase domain containing 2
chr12_-_122326516 0.220 NM_001171993
HPD
4-hydroxyphenylpyruvate dioxygenase
chr1_-_152386727 0.220 NM_016190
CRNN
cornulin
chr11_-_111636995 0.219 PPP2R1B
protein phosphatase 2, regulatory subunit A, beta
chr1_+_244216506 0.219 NM_006352
ZNF238
zinc finger protein 238
chr6_+_31913708 0.219 NM_001710
CFB
complement factor B
chr7_+_142919129 0.219 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr5_-_138862224 0.218 TMEM173
transmembrane protein 173
chr2_+_171571800 0.218 NM_001003845
SP5
Sp5 transcription factor
chr3_+_63884074 0.217 NM_001177387
ATXN7
ataxin 7
chr12_-_117799410 0.217 NM_000620
NM_001204218
NOS1

nitric oxide synthase 1 (neuronal)

chr16_+_6823809 0.217 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_-_150920946 0.216 NM_013308
GPR171
G protein-coupled receptor 171
chr4_+_175839508 0.216 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr14_-_80697396 0.216 NM_000793
DIO2
deiodinase, iodothyronine, type II
chrX_-_48056198 0.214 NM_021015
NM_175723
SSX5

synovial sarcoma, X breakpoint 5

chr10_+_126630691 0.213 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr1_+_167298280 0.213 NM_001198783
POU2F1
POU class 2 homeobox 1
chr10_-_75335415 0.212 NM_152586
USP54
ubiquitin specific peptidase 54
chr7_-_138363789 0.212 NM_001139456
SVOPL
SVOP-like

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.12 1.51e-02 GO:0065007 biological regulation
1.16 1.85e-02 GO:0032501 multicellular organismal process
1.12 3.21e-02 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 3.84e-04 GO:0005576 extracellular region
1.46 4.73e-04 GO:0044421 extracellular region part
1.48 4.23e-03 GO:0005615 extracellular space
1.36 2.83e-02 GO:0000267 cell fraction
1.41 3.47e-02 GO:0005626 insoluble fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.54 5.28e-03 GO:0005509 calcium ion binding